physician global assessment sle

Glossary: PGA. An acceptable reliability is indicated by values of intraclass correlation coefficient (ICC) or weighted >0.60 and a good reliability is >0.85 [20]. All rights reserved. The judgment of whether a patient with SLE has active disease is a central question both in routine patient management and in clinical research [4]. Methods Petri M (PGA)and physician global assessment of disease activity (PHGA), C3, C4 and Anti-ds Anti-DNA titer abnormalities, and a formula incorporating the current . Learn more. Medizinische Universitt Graz Austria/sterreich - Forschungsportal - Medical University of Graz Direkt zur Navigaton springen . Beaton DE Ensure second line of defense Derivatives RWA reviews are performed consistently and . Associations between physicians' global assessment of disease activity JBT-101 in Systemic Lupus Erythematosus (SLE) Thousand Oaks. This week's edition of Faculty Publications includes Cedars-Sinai studies that were published Feb. 23-March 2. On stratifying the results by individual clinician, values ranged from 0.61 to 0.90, except for those reported by . Liang et al. Because of its dynamic nature, this disease has an unpredictable natural course leading to high . , Skogh T Global Automatic Chemiluminescence Immunoassay Analyzer Market 2023 et al. The 4-point PGA (0, no flare; 1, mild; 2, moderate; 3, severe) showed the lowest IRR in assessing flare (ICC=0.18) compared with the BILAG-2004 (ICC=0.54) and SFI (ICC=0.21) [65]. It was published in 1977 and was initially designed for the measurement of self-assessed pain in rheumatoid arthritis although it has since been used to evaluate RA more globally. SLE is an autoimmune disease in which the immune system attacks its own tissues, causing widespread inflammation and tissue damage in the affected organs. , Vogel-Claussen J et al. The PGA intraRR was assessed in three studies [10, 68, 94] and ranged from 0.55 [68] to 0.88 [10]. et al. Patient-Reported Outcomes in Systemic Lupus Erythematosus. , Ho LY , Mosca M Franklyn K , Pilkington C The quantification of reliability is expressed by a correlation coefficient. AU - Louthrenoo, Worawit. et al. , Sengupta M CareerBuilder TIP. Annapureddy N This study assesses the reliability of the PGA, measured by means of 0-100 mm visual analog scale (VAS), and the additional use of separate VAS scales for musculoskeletal (PhysMSK) and dermatologic (PhysSk) manifestations in patients with psoriatic arthritis (PsA). PDF Getting To Know Dr. Derek Shendell, New Safe Schools Project Director 12. and later incorporated into the SLE Responder Index used in the belimumab clinical trials, 13 J Clin Med. Intoduction to X 20 - Physician Global Assessment , Urowitz MB Physician global assessments for disease activity in rheumatoid arthritis are all over the map!. The literature search identified 91 studies. [8] suggested the need for a disease activity instrument that would be valid, reliable and sensitive to change. The .gov means its official. , Gladman DD. Five centres in Great Britain and the Republic of Ireland have collaborated to produce a computerized index of clinical disease activity in systemic lupus erythematosus, based on the principle of the physician's intention to treat. , Petri M Strength. , Allen E Can Lupus Patients Take the Driver's Seat in Their Disease Monitoring. The company serves physicians and patients. Use of Physician Global Assessment in systemic lupus erythematosus: a Criterion validity also refers to the degree to which an instrument predicts aspects and phenomena occurring in the future [108]. Visual analogue scales (VAS) allow rapid, continuous scaling of disease severity. , Genovese M , Fortin PR They participate in physiologic and inflammatory cascades and have become a major focus of research, yielding novel therapies for immune-mediated inflammatory diseases (IMID). Genetic linkage has related dysfunction of . PGA is a valid, responsive and feasible instrument, though its reliability was impacted by the scale adopted, suggesting the major need for standardization of its scoring. Exagen's products are used for therapeutic drug monitoring of hydroxychloroquine in whole blood and methotrexate polyglutamates, risk assessment testing, anti-TNF monitoring to individualize therapy and optimize dosing, and others. Physician Global Assessment (PGA) is a visual analogue score (VAS) that reflects the clinician's judgment of overall Systemic Lupus Erythematosus (SLE) disease activity. Different scores and lengths of visual evaluation were employed: the first was the 010 VAS suggested by Liang et al. Cutaneous lupus erythematosus (CLE) is an autoimmune skin disease that can occur with or without systemic lupus erythematosus (SLE). Correspondence to: Laurent Arnaud, Service de Rhumatologie, Centre National de Rfrence des Maladies Autoimmunes et Systmiques Rares, Hpital de Hautepierre, 1 Avenue Molire BP 83049, 67098 Strasbourg Cedex, France. Neuropsychiatry OXFORD TEXTBOOKS IN PSYCHIATRY Oxford Textbook of Neuropsychiatry Edited by Niruj Agrawal, Rafey Faruqui, and Mayur Bodani Oxford Textbook of Psychiatry of Intellectual Disability Edited by Sabyasachi Bhaumik and Regi Alexander Oxford Textbook of Inpatient Psychiatry Edited by Alvaro Barrera, Caroline Attard, and Rob Chaplin Oxford Textbook of Attention . Reliability measures the reproducibility of the instrument: it refers to the degree of agreement between different observers (interrater) and in the same observer over time (intrarater). Systemic Lupus Erythematosus (SLE) | CDC , Kharboutli M Piga M Construct validity was recognized in 21 studies [2, 10, 11, 23, 24, 2629, 35, 47, 52, 54, 65, 68, 76, 84, 88, 92, 99, 101]. The aim of this systematic literature review (SLR) is to describe and analyse the psychometric properties of PGA. , Lau CS PGA-IGA described in ePROVIDE - Mapi Research Trust Face validity. et al. Unable to load your collection due to an error, Unable to load your delegates due to an error. , Nelson S , Ibaez D , Friebus-Kardash J The visual analog scale (VAS)-based assessments, SELENA SLE Disease Activity Index (SLEDAI) Physician's Global Assessment (SSPGA) and Lupus Foundation of America-Rapid Evaluation of Activity in Lupus (LFA-REAL), can be used to assess common trial end points for systemic lupus erythematosus (SLE), according to study results published in Lupus Science & Medicine. watch for seizures after the procedure. COSMIN Terminology from a European Rheumatology Perspective: a Glossary for the EULAR PRO Tool Box Initiative. If you have a published paper from this period that does not appear on this list, please contact Sue Marone, who will add it to next week's collection. et al. , Bertsias G , Tanangunan R , Birmingham DJ , Fang H Help us improve CareerBuilder by providing feedback about this job: Report this job Job ID: 2281236908. The official NJDOE Incident Reporting Form, as well as a guide to completing , Jnsen A Reviews and case series with fewer than five patients were excluded. In Fatemi et al. Frontiers | Cutaneous lupus erythematosus disease assessment et al. [PDF] Use of Physician Global Assessment in systemic lupus , Adamichou C , Weisman MH. , Lin M , Jolly M. Antony A Pain assessment: An alternative measure - hcplive.com Dynabook PX1900E-1NCA, PROTECTIVE SLE (PX1900E-1NCA) Even though the PGA showed optimal reliability, a very low interRR for flare using the PGA (ICC=0.18) was found in a single study [65] compared with that of the BILAG (ICC=0.54) or SFI (ICC=0.21). Feasibility refers not to the quality of the outcome measure, but to aspects such as completion time, cost of an instrument, equipment and type and ease of administration. , Magder LS independently selected the articles, initially on the basis of titles and abstracts, then, if necessary, on the full texts, an eligibility assessment was performed independently in a blinded standardized manner. 2014 - 20184 years. [9] for a disease activity index scored on a VAS ranging from 0 to 3, with an increase of 1.0 since the last visit indicating a flare. et al. Disagreements between investigators were solved by consensus. , Bocci EB Systemic Lupus Erythematosus and Lupus Nephritis - Epidemiology et al. This is a top barrier, both for treat-to-target management of SLE patients in clinical practice, as well as in clinical trials for new SLE treatments. , Gayet-Ageron A Bookshelf [8] suggested that the PGA should account for objective examination, laboratory results and what patients report. , Merrill JT. Unauthorized use of these marks is strictly prohibited. Mokkink LB Medical-Surgical Nursing Clinical Lab (NUR1211L) U.S. History Themes (HIS-144) Nursing Process IV: Medical-Surgical Nursing (NUR 411) Maternity Nursing Care; Professional Roles and Values (C 304) Survey of United States History (C121) Trending. (SLE) GSKpro Petri M , Lerman RH The anonymous patientcompleted questionnaire comprised the following: current pain in the past 7 days (10cm VAS [0 no pain; 10 most severe pain]), patient global assessment (PtGA) of health status (10 cm VAS [0 very well; 10 very poorly]), ever and current recreational cannabis use, ever and current medical cannabis use, and if cannabis . et al. AU - Morand, Eric. , Floris A Your recommendations as to what might or should be done in relation to various issues observed. Three studies evaluated the association between PGA scores and treatment changes: PGA correlated negatively with adherence to treatment assessed through an item scale (r=0.31, P=0.11) [34]; clinically defined mild and moderate flares had a higher disease activity by the PGA (P<0.001) than those defined as mild/moderate flare only by medication changes [55]; PGA scores were associated positively with response to belimumab treatment (P=0.039) [43]. The term Physician Global Assessment (PGA) was coined in 1991 by Petri et al. , Bentow C All articles published through 1 July 2019 in PubMed were screened, with no limitation on year of publication, language or patients age. An international panel of 79 SLE experts participated in a three-round Delphi consensus . The PGA was developed on a 0 to 3 scale as part of the Lupus Activity Index. , Mazur M. Fatemi A The PGA was introduced in 1998 by a US Food and Drug Administration panel as the preferred tool to assess and record the severity of disease in clinical studies, and typically rates a patient's disease from 'clear' to 'severe' or 'very severe' [1, 2]. Psychometric properties of FACIT-Fatigue in systemic lupus erythematosus: a pooled analysis of three phase 3 randomised, double-blind, parallel-group controlled studies (BLISS-SC, BLISS-52, BLISS-76). Newark, New Castle, USA, March 03, 2023 (GLOBE NEWSWIRE) -- The global complement-targeted therapeutics market is expected to grow at a CAGR of 8.9% from 2022 to 2030, owing to the rising . 2022 Sep 20;19(19):11895. doi: 10.3390/ijerph191911895. antineutrophil cytoplasmic antibody-associated vasculitis (AAV), and systemic lupus erythematosus (SLE). According to the OMERACT, face validity is the degree to which the instrument appears to match with the target domain, according to experts [18]. Moreover, a difference between the interRR of the PGA assessed by an untrained physician (0.50.63) and a trained investigator (0.790.81) was found, suggesting the need for PGA scoring training or standardization [36]. Barr SG The intrarater reliability (intraRR) is the ability to provide consistent scores in a stable population by the same assessor over time. The authors wish to thank Sylvie Thuong for her invaluable assistance in the preparation of this manuscript. The aim of this systematic literature review (SLR) is to describe and analyse the psychometric properties of PGA. Would you like email updates of new search results? PGA is a valid, responsive and feasible instrument, though its reliability was impacted by the scale adopted, suggesting the major need for standardization of its scoring. Treatment of lupus nephritis: consensus, evidence and perspectives , Taghavi-Zadeh S Subsequently the PGA was incorporated in the Safety of Estrogen in Lupus Erythematosus National Assessment (SELENA) flare index (SFI) in 1999 [10], in the Systemic Responder Index (SRI) in 2009 [3, 11, 12] as well as in the definitions of the Lupus Low Disease Activity State (LLDAS) [13] and various definitions of remission [14, 15]. , Perez-Gutthann S Diet and Systemic Lupus Erythematosus (SLE): From Supplementation to Intervention. Reliability was excellent when scored through a pointed scale, such as the Likert scale, that was anchored in unit numbers from 0 (not active) to 7 (most active) (interRR ICC 0.96; intraRR ICC 0.88) [80], but was lower when assessed through a centimetric VAS using values between 0.0 and 3.0 (interRR ICC 0.67; intraRR ICC 0.55) [68]. The Physician Global Assessment (PGA) is a visual analogue score that reflects the clinician's judgement of overall SLE disease activity. et al. Physician's global assessment is often useful in SLE - ResearchGate The literature search identified 91 studies. , Urowitz MB , Jolly M. Ribi C ECG - correct answer no sleep the night before, meals allowed, no stimulants/tranquilizers for 24-48 hours before. 2014 Dec;53(12):2175-81. doi: 10.1093/rheumatology/keu153. A high variability in scales was found, causing a wide range of reliability (intraclass correlation coefficient 0.670.98). , Petri M. Iaccarino L , Ibanez D , Kalunian K The literature search identified 93 articles, and 12 additional articles were retrieved from the reference list of those publications. 2. physician global assessment (pga) - Assesschild Arthritis Res Ther. , Askanase A et al. http://oml.eular.org/glossary (31 January. Notorious to increase IOP and cause severe PAIN and headache; Diagnostics: - History - Tonometry examinations - measures IOP QUESTION A client states that the physician has told her that her intraocular was 14. . No data were found regarding the feasibility of the PGA. Disclosure statement: L.A. is a consultant for Alexion, Amgen, AstraZeneca, GlaxoSmithKline, Janssen-Cilag, LFB, Eli Lilly, Menarini France, Novartis, Pfizer, Roche-Chugai and UCB. Construct validity is shown by the good correlation observed with the SLEDAI, BILAG, SLAM, LAI and ECLAM [10, 23, 24, 26, 28, 29, 35, 54, 68, 76, 84, 99]. 3TR (Taxonomy, Treatment, Targets and Remission) Systemic Lupus It should be noted that the PGA correlates with several other instruments that measure disease activity. All articles published through 1 July 2019 in PubMed were screened, with no limitation on year of publication, language or patients' age. , Wallace DJ , Garabajiu M Moreover, there is uncertainty as to whether the best timing of assessment is prior to or after reviewing laboratory exams [26]. , Piette EW Criterion validity is defined as the degree to which the scores of an instrument adequately reflect the truth in the form of a gold standard [107]. T1 - Associations between physicians' global assessment of disease activity and patient-reported outcomes in patients with systemic lupus erythematosus. official website and that any information you provide is encrypted , ODell JR Systemic lupus erythematosus (SLE), is the most common type of lupus. Content validity was reported in 89 studies. , Jolly M. Mazur-Nicorici L , Bresee C ~SLE~. Physician Global Assessment to Track Outcomes - JAMA doi: 10.1136/rmdopen-2022-002395. , Chang AY , Koutsoviti S Pincus and colleagues conducted a study of . , Magder LS Face validity is satisfied when the instrument is considered able to capture what it should capture (i.e. The last MEDLINE search was performed on 1 July 2019. , Seaman AL , Rodrigues M , Mikolaitis-Preuss RA , Goldsmith CH Akhter E RN-BSN HOLISTIC HEALTH ASSESSMENT ACROSS THE LIFESPAN (NURS 3315) Sociology of Social Problems (SOC213) Use of Physician Global Assessment in systemic lupus - PubMed Trusted for over 30 years to provide and transform technology into complete solutions that advance the value of IT. To discriminate between the severity of flares, the PGA was incorporated in a composite index: the SFI [10] (Table1). Uribe AG, Vil LM, McGwin G Jr, Sanchez ML, Reveille JD, Alarcn GS. Castrejn I, Ra-Figueroa I, Rosario MP, Carmona L. Reumatol Clin. The results are similar, and less than half the time is required for scoring. Identification of new candidate drugs for primary Sjgrens syndrome using a drug repurposing transcriptomic approach, When it looks like Behets syndrome but is something else: Differential diagnosis of Behcets syndrome: a two-centre retrospective analysis, Huge water-balloons in the belly: multiple pancreatic pseudocysts in systemic lupus erythematosus, A randomized, double-blind, placebo-controlled, parallel group study on the effects of a cathepsin S inhibitor in primary Sjgrens syndrome, How to plug the leaky pipeline in clinical rheumatology across Europelessons to be learned from experiences in business, About the British Society for Rheumatology, British Society for Rheumatology Journals, https://doi.org/10.1093/rheumatology/keaa383, https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model, Receive exclusive offers and updates from Oxford Academic, Copyright 2023 British Society for Rheumatology. , Block JA 25 (FIVE YEARS 8) Latest Documents Most Cited Documents Contributed Authors Related Sources Related Keywords Latest Documents; Most Cited Documents; Contributed Authors; Related Sources; Funding: The study was funded through the training Bursary Programme 2019 of the SLEuro European Lupus Society. Mina R may be asked to hyperventilate 3-4 min and watch a bright flashing light. The PGA is a well accepted and commonly used scale for evaluating treatment response in clinical trials both in adults and children. A good responsiveness for PGA was shown in eight studies. , Jolly M. Mok CC Conclusion: T2 - A longitudinal study. Methods: The measurements were in the form of a scale from 0 to 3 in 54 studies [2, 3, 9, 10, 12, 13, 21, 2469, 103], a 010 scale in 12 studies [4, 60, 7079], a 0100 scale in 9 studies [27, 40, 78, 8085], a 07 Likert scale [11, 78, 80], a 02 scale [53], a 04 scale [86] and a 05 scale [87]. New Tools to Measure Disease Activity in SLE - Rheumatology Network Derivatives RWA Production Controller (SA-CCR/SLE) Different definitions of PGA retrieved through the literature search are reported in Table1. inflammation (duration and severity of morning stiffness as measured by BASDAI). , Petri MA , Smiley A. Askanase AD PGA is an important tool for assessing disease activity, response to treatment (it is a component . . Face validity was reported in all the articles retrieved in which the PGA was used alone or as part of composite indices (Systemic Responder Index, Safety of Estrogen in Lupus Erythematosus National Assessment Flare Index, Lupus Low Disease Activity State, Definitions of Remission in Systemic Lupus Erythematosus criteria).

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